Six noreudesmane sesquiterpenoids from Dobinea delavayi and their lipid-lowering and antimalarial activities
来源：本地 作者：肖朝江 发布时间：2025-04-15 15:44 点击次数：
Six undescribed noreudesmane sesquiterpenoids (dobinins V-Z, and AA; 1-6) were isolated from Dobinea delavayi, including 1 as the first example of 7,8-seco-11,12,13-trinoreudesmane sesquiterpenoids with a unique skeleton fusing by a cyclohexane and a six-membered lactone. NMR and HR-ESI-MS spectroscopies were used to identify the structures of dobinins V-Z, and AA, and single-crystal X-ray diffraction experiment was conducted to verify the structure of dobinin V. A biosynthetic pathway of dobinins V-Z, and AA was suggested based on the structure. The isolated compounds were tested in vitro for lipid-lowering activity and for antimalarial activity against Plasmodium falciparum 3D7. Eudesmane sesquiterpenoids were discovered to have lipid-lowering activity for the first time.（全文链接）
上一篇：没有了
下一篇：西南绣球茎和根乙醇提取物中的三萜类成分及其体外抗疟活性