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Two new benzophenones from Dobinea delavayi
来源:本地   作者:肖朝江   发布时间:2021-11-22 15:28   点击次数:

 Two new benzophenones, 2,6,3′,4′-tetrahydroxy-4-methoxybenzophenone (1) and 2,6,4′-trihydroxy-4,3′-dimethoxybenzophenone (2), together with four known phenolic compounds (3-6) were isolated from the roots of Dobinea delavayi (Anacardiaceae). Structures of the isolated compounds were determined by the comprehensive analyses of the physicochemical properties and spectral data (NMR and MS). In vitro antimalarial activity and cytotoxicity of isolated compounds were evaluated by β-hematin formation inhibition assay and MTT colorimetric assay, respectively. Compound 6 exhibited significant in vitro antimalarial activity with IC50 value of 42.1 μg/mL. Compound 4 exhibited weak cytotoxicity against HepG2 and MCF-7 cells with IC50 values of 169.2 and 192.0 μg/mL. 全文链接

Two new benzophenones from Dobinea delavayi(www.kongbutu.net)

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