当前位置:首页 > 研究进展 >
Antimalarial eudesmane sesquiterpenoids from Dobinea delavayi
来源:本地   作者:肖朝江   发布时间:2020-06-08 20:13   点击次数:
 Eleven new angeloylated eudesmane sesquiterpenoids, dobinins D–N (235689, and 1115), and four known compounds (147, and 10) were isolated from the roots of Dobinea delavayi. A new oxidation product (8a) was also obtained from dobinin H (8). Their structures were elucidated by spectroscopic data and single-crystal X-ray diffraction analyses. Dobinins K–N (1215) are the first examples of rearrangement noreudesmane analogue sesquiterpenoids with a unique 6/5-fused carbon skeleton. A putative biosynthetic pathway of compounds 1215 is proposed. Compound 12 exhibited significant antimalarial activity superior to artemisinin with the inhibition ratio of 59.1%, and compounds 35, and 15 exhibited moderate antimalarial activities against Plasmodium yoelii BY265RFP with inhibition ratios ranging from 14.5% to 18.5% at a dose of 30 mg/kg/day. In addition, the apoptosis of P. yoelii BY265RFP by the depolarization of mitochondrial membrane potential with striking ROS production, after parasitized erythrocyte lysis mediated by cytokines IL-12 and IFN-γ, may be a possible mechanism of antimalarial action of compound 12 against P. yoelii BY265RFP.(全文链接

Antimalarial eudesmane sesquiterpenoids from Dobinea delavayi(www.kongbutu.net)

上一篇:Dodelates A-E: five dimeric eudesmane sesquiterpenoids from Dobinea delavayi
下一篇:没有了

首页    |     研究所概况    |     研究团队    |     研究成果    |     新闻动态    |     研究进展    |     学术交流    |     人才培养    |     科普与生活    |